Description Balance sleep/wake cycles ✔ Jet lag, shift work, anti-aging ✔ Fast acting, non-addictive ✔ Wake refreshed, no morning hangover ✔ Achieve deeper stage 4 sleep as required for detoxification Melatonin B6 Spray is formulated to promote natural sleep. Decreased melatonin production and sleep issues can develop with aging and lifestyle factors (artificial light, shift work, late night/altered sleep schedules, and exposure to electrosmog including laptops, television, and computers). Taking melatonin helps regulate sleep-wake cycles, resets circadian rhythms, increases REM and total sleep time, and improve overall sleep quality. When combined with vitamin B6, melatonin biosynthesis, secretion and absorption is enhanced. Melatonin is used to support difficulty falling asleep (delay sleep phase syndrome), waking in the night, jet lag, increasing total sleep time (shift work, jet lag, late night/altered sleep schedule). Research shows that melatonin benefits goes beyond improving overall quality of sleep. Known at one of the body’s most efficient free-radical scavengers, melatonin has powerful antioxidant, anti-inflammatory and immune properties for brain, neurological, heart, and cancer protection. Sleep Hygiene Follow consistent and good sleep habits and bedtime routine Melatonin relies on environmental light cues, with darkness as the trigger to increase production. Therefore, one hour before bed: no electronics should be used (this includes computers, TV, or cell phone), all lights should be dimmed, no exposure to bright light (ex. don’t turn on bathroom light to brush teeth). For the best results with melatonin, the bedroom should be pitch-black throughout the night with no ambient light emission (alarm clocks, street lights Individualized Melatonin Dosage • Difficulty falling asleep – Take 1-10 sprays or 1 lozenge (10mg) of melatonin 30 minutes to 1 hour before bedtime. • Nighttime awakening and early morning insomnia – Keep on bedside table and take 1-10 sprays or 1 lozenge (10mg) upon waking (do not take within 1 hour of getting up in the morning). • Jet lag – Take 1 hour before desired bedtime after darkness in new destination until adaptation to new daily pattern. Especially effective when traveling eastbound over 2 or moretime zones. • Shift work – Take 1-10 sprays or 1 lozenge (10mg) of melatonin several hours before planning on sleep (note: avoid driving, direct sunlight or bright light after taking melatonin). • Age-related sleep aid – Effectiveness of melatonin may increase with advancing age due to calcification of the pineal gland and decreased pineal-derived melatonin availability – take 1-10 sprays or 1 lozenge (10mg) of melatonin 30 min to 1 hour before bedtime • For patients that ‘do not do well’ on melatonin (restless, sleep worse, too stimulating), take 1 to 10 sprays or 1 lozenge (10mg) of melatonin with 1 tsp (4 g) of glycine. Glycine has shown to improve melatonin tolerance, as it acts as a serotonin re-uptake inhibitor and decreases core body temperature to match physiological temperature during sleep. Also consider underlying symptoms of dysbiosis and liver function Medicinal Ingredients: Each single spray contains: • Melatonin 1 mg • Vitamin B6 (Pyridoxine hydrochloride) 1 mg Non-medicinal ingredients: Filtered water, glycerin, alcohol, stevia extract, mint flavor, potassium sorbate Suitable for vegetarians. Recommended Dosage: Adult: Spritz 1 to 10 sprays under the tongue before or at bedtime, or as directed by a health care practitioner. 60 ml (360 sprays) NPN 80082182 Product of Biomed



